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Hoodia Diet Reviews - Learn which Hoodia diet pills suppress the appetite best!

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Hoodia P57 Appetite Suppressant Molecule

What is Hoodia P57 Molecule?

P57 is extracted from the Hoodia Gordonii, a cactus like plant. Hoodia Gordonii is a South African plant which has been eaten by Bushmen for thousands of years to stave off thirst and hunger during long hunting trips.

Phytopharm has six patents in progress covering the use of the plant, its active molecules, derivatives and mode of action.  In 1997 Phytopharm licensed the rights to P57 from the Council for Scientific and Industrial Research in South Africa. Then, in 1998, Pfizer acquired the rights to develop and market P57 world-wide, with Phytopharm receiving up to $32 million in license fees, in addition to royalties on sales. Pfizer made a payment of $1 million to Phytopharm April 29, 2000 on completion of the phase I dose escalation studies. The agreement was extended in August 2000 to enable further collaborative research. Pfizer has already contributed over $8 million to the drug's development.

In a July 2001 press release, Phytopharm announced the successful completion of its phase I "proof of principle" trial.  Evaluations have been conducted to study the safety, tolerability and pharmacogology of single doses of the product.  Moreover, studies to assesses the effects of repeated dosing, in healthy overweight volunteers has also been conducted. The data obtained from these evaluations was used to determine the dosing regimen (dose and duration) for the final repeat dose stage.  Industry experts predict that if all goes well this drug will be available on pharmacy shelves in three years.

P57 the molecule in the plant Hoodia Gordonii that has been studied to aid in suppression of appetite leading to its use for the treatment of obesity.  While results to date are very promising, Hoodia P57 is currently in clinical trials which can take years to refine and obtain pre-requisite data for approval as a drug.  Initial Hoodia P57 was licensed to Pfizer Inc. in 1998 and millions were spent to try and economically sythesis the P57 molecule without success thus far.  Only the natural plant, Hoodia Gordonii have proven to offer the P57 molecule at an economical cost.


Pharmacology of Hoodia Gordonii P57 Molecule

Reports of the use of P57 in humans show that it can significantly reduce appetite, food intake and body weight. The properties and makeup of the Hoodia Gordonii P57 molecule is under investigation.

Hoodia Gordonii's P57 seems to have pharmacological appeite suppressant properties and may indeed be a truly powerful appetite suppressant with no kowns side effects to be discovered. Thus far, efficacy has been established with a profound weight loss and a good emergent safety profile.  Phase I clinical trials continue while simultaneously cultivation in large Hoodia plantations have and continue to be established in collaboration with the CSIR and Pfizer in South Africa.


Clinical Studies Hoodia Gordoniii P57 Molecule

To date 24 obese (BMI>26) and 42 non-obese non-patient volunteers have received doses of P57 ranging from 3 to 4000 mg. Primary measures in these studies included clinical toleration, haematological and biochemical assessments of safety and pharmacokinetics. No treatment related adverse events have been reported.


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Hoodia Cactus